4-hydroxybutyric acid analogs

A pharmaceutical composition comprising an effective amount of a compound of Formula IV

• wherein:
• A is hydrogen, deuterium, —CH2—C(O)OR2 or —CH(R1)—C(O)OR2;
• R1 is a C1-6 alkyl, C2-10 alkoxyalkyl, or C3-6 cycloalkyl group that is optionally substituted by an R3 group;
• R3 is C1-3 alkyl, C1-3 alkoxy, phenyl, —O—(CH2CH2O)n—CH3, or -(heterocyclyl)-C1-3 alkyl where the heterocyclyl moiety is a four to six-membered ring having an oxygen ring atom;
• n is 1, 2, or 3;
• R2 is hydrogen, deuterium, —C1-4 alkyl, —C1-4 alkyl-phenyl, —C3-6 cycloalkyl, —C3-6 cycloalkyl-phenyl, —CH2—(C3-6 cycloalkyl), —CH2—(C3-6 cycloalkyl)-phenyl, phenyl, or biphenyl;
• X is hydrogen, deuterium, —C(O)-indanyl, —C(O)-indenyl, —C(O)-tetrahydronaphthyl, —C(O)—C1-6 alkyl, —C(O)—C1-6 alkenyl, —C(O)—C1-6 alkynyl, —C(O)—C1-3 alkyl-(C3-6 cycloalkyl), or —C(O)—C3-6 cycloalkyl optionally substituted by C1-6 alkyl, phenyl or naphthyl;
• and
• each Y is independently selected from hydrogen and deuterium,
• or a pharmaceutically acceptable salt thereof;
• and a pharmaceutically acceptable carrier.