Film-forming composition for a ph-dependant sustained release of the active agent
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsMichael Friedman, Doron Steinberg, Eran Lavy
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Abstract
The present invention discloses a liquid precursor composition adapted for application on a on a desired surface, this composition comprising: a. at least one therapeutic agent suitable for the treatment or prevention of a disorder or pathological condition, wherein said disorder or pathological condition excludes oral disorders, b. at least one acidic-pH sensitive polymer, c. at least one hydrophobic polymer, and d. a pharmaceutically acceptable volatile solvent, wherein a weight ratio between the at least one hydrophobic polymer and the at least one acidic-pH sensitive polymer is larger than 1.
Claims17
1-19. (canceled)
A method for treating an infection or preventing an infection from forming comprising administering to a patient in need thereof, excluding oral cavity, a medical device, said device being coated by a sustained release formulation, comprising a matrix of
- at least one hydrophobic polymer, having embedded within
- at least one acidic-pH sensitive polymer and
- at least one therapeutic agent for the treatment or prevention of the infection,
- wherein the weight ratio between said at least one hydrophobic polymer and said at least one acidic-pH sensitive polymer is larger than 1, wherein said at least one acidic-pH sensitive polymer has an enhanced solubility at about or below pH 6.0, and wherein said infection is characterized by the reduction of the pH.
Dependencies are inferred from the claim text.