Inclusion complexes and methods for making the same
AssigneeThe Board of Trustees of the University of llinois
InventorsJoseph D. Donovan, Soo-Yeun Lee, Youngsoo Lee
Life of this patent
Estimating the term…
Abstract
The invention provides novel formulations comprising a stable inclusion complex of tributyrin and a cyclodextrin. In one particular embodiment, the formulation comprises an oven dried inclusion complex of tributyrin and γ-cyclodextrin that is effective in minimizing or preventing the unpleasant taste and odor of tributyrin, thus making it suitable for oral administration and delivery to the digestive tract and intestines. The invention provides compositions of these inclusion complexes and methods of using them that are advantageous as food, medicinal and other products, where the negative sensory properties of tributyrin can be a liability.
Claims21
1-20. (canceled)
A stable inclusion complex comprising tributyrin and a cyclodextrin, wherein the inclusion complex is olfactorily and gustorialy neutral in comparison to free tributyrin.
A method of preparing a stable inclusion complex comprising:
- a) mixing trubutyrin and γ-cyclodextrin in water to form a first inclusion complex;
- and
- b1) drying the first inclusion complex for a sufficient period of time to form a stable inclusion complex at a temperature that does not degrade the stable inclusion complex;
- or
- b2) drying the first inclusion complex for a sufficient period of time to form a stable inclusion complex that has a moisture content of less than about 11%;
- wherein the stable inclusion complex has a taste and odor that is indistinguishable from a γ-cyclodextrin that does not comprise tributyrin.
Dependencies are inferred from the claim text.