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US 2019/0099482 A1Published application
Liposomal flu vaccine formulation
AssigneeSouthwest Research Institute
InventorsXingguo CHENG, Kenneth H. CARSON, Joseph A. McDONOUGH, Renukaradhya J. GOURAPURA, Chang Won LEE, Santosh DHAKAL
Life of this patent
Estimating the term…
Abstract
The present invention relates to the field of pharmaceutical and vaccine formulations. More specifically, formulations which comprise an antigen comprising a mixture of oligopeptides loaded into liposome nanoparticles, optionally including an adjuvant, to provide an improved immune response.
Claims20
An immunogenic composition comprising:
- SEQ ID NO:
- 1 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 1;
- SEQ ID NO:
- 2 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 2;
- SEQ ID NO:
- 3 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 3;
- SEQ ID NO:
- 4 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 4;
- SEQ ID NO:
- 5 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 5;
- SEQ ID NO:
- 6 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 6;
- SEQ ID NO:
- 7 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 7;
- SEQ ID NO:
- 8 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 8;
- SEQ ID NO:
- 9 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 9;
- and
- SEQ ID NO:
- 10 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 10.
28 more elements
An immunogenic composition comprising:
- SEQ ID NO:
- 1 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 1;
- SEQ ID NO:
- 2 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 2;
- SEQ ID NO:
- 3 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 3;
- SEQ ID NO:
- 4 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 4;
- SEQ ID NO:
- 5 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 5;
- SEQ ID NO:
- 6 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 6;
- SEQ ID NO:
- 7 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 7;
- SEQ ID NO:
- 8 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 8;
- SEQ ID NO:
- 9 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 9;
- and
- SEQ ID NO:
- 10 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 10;
- and
- an adjuvant comprises mono sodium urate present at a level of 1.0 mg to 10.0 mg.
30 more elements
A method for eliciting an immune response and conferring protection against influenza virus in a subject, wherein the method comprises administering to the subject a vaccine comprising:
- SEQ ID NO:
- 1 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 1;
- SEQ ID NO:
- 2 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 2;
- SEQ ID NO:
- 3 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 3;
- SEQ ID NO:
- 4 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 4;
- SEQ ID NO:
- 5 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 5;
- SEQ ID NO:
- 6 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 6;
- SEQ ID NO:
- 7 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 7;
- SEQ ID NO:
- 8 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 8;
- SEQ ID NO:
- 9 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 9;
- and
- SEQ ID NO:
- 10 or an oligopeptide having 90% or more amino acid sequence identity to SEQ ID NO:
- 10;
- to elicit an immune response and confer protection against influenza virus.
29 more elements
Dependencies are inferred from the claim text.