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US 2019/0099478 A1Published application
Vaccines against Chlamydia sp.
AssigneeStatens Serum Institut
InventorsFrank Follmann, Ida Kosenkrands, Anja Olsen, Peter Andersen
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Abstract
The present invention describes an efficient vaccine against a Chlamydia trachomatis (Ct). The vaccine is based on recombinant fusion molecules that are capable of generating a high titered neutralizing antibody response that is protective against various Ct serovars. Our invention furthermore describe the combination of these antibody promoting fragments with Ct antigens that are targets for T cells with the aim to provide a vaccine that activate both arms of the immune system.
Claims1
1:
- A polypeptide comprising 3 or more immuno-repeat units of surface exposed fragments of the major outer membrane protein (MOMP), wherein each immuno-repeat comprises an amino acid sequence which comprises the variable domain 4 (VD4) region of the MOMP chosen from any Chlamydia sp. serotype.