Methods for reducing severity of pulmonary fibrosis
AssigneeCedars-Sinai Medical Center
InventorsCarol Jiurong Liang, Dianhua Jiang, Paul W. Noble
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Abstract
The described invention provides a method of treating a lung injury at risk of progressing to a fibrotic lung disease in a subject in need thereof comprising administering to the subject a composition comprising a therapeutic amount of IL-6 polypeptide, hyaluronan (HA), mimetics thereof, pharmaceutically acceptable salts thereof, or combinations thereof, wherein the therapeutic amount is effective to increase renewal of alveolar epithelial cell 2 (AEC2) stem cells, to repair the injury, to reduce lung fibrosis, or a combination thereof.
Claims28
A method of treating a lung injury at risk of progressing to a fibrotic lung disease in a subject in need thereof comprising administering to the subject a pharmaceutical composition comprising a therapeutic amount of IL-6 polypeptide, hyaluronan (HA), mimetic s thereof, or pharmaceutically acceptable salts thereof, wherein the therapeutic amount is effective to increase renewal of alveolar epithelial cell 2 (AEC2) stem cells, to repair the injury, to reduce lung fibrosis, or a combination thereof.
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A method of increasing alveolar epithelial cell 2 (AEC2) stem cell renewal in a lung to reduce progression of a lung injury to a fibrotic disease in a subject in need thereof comprising administering to the subject a pharmaceutical composition comprising a therapeutic amount of IL-6 polypeptide, hyaluronan (HA), or mimetics thereof, pharmaceutically acceptable salts thereof.
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Dependencies are inferred from the claim text.