Loading patent…
AssigneeTrustees of Tufts College
InventorsAndrew Camilli, Lynne Cairns, Minmin Yen
Estimating the term…
Compositions and methods are provided for preventing, ameliorating, or treating a disease caused by a species of bacterial genus Vibrio, for example, cholera caused by V. cholerae, the compositions containing two or more strains of lytic bacteriophage that infect and kill Vibrio cells. The bacteriophage are virulent, which replicate intracellularly and lyse and kill the bacteria. Use of two or more strains in a single treatment, as a result of a rate of mutation of the bacteria to simultaneous resistance to all of the bacteriophage to be so low as to be negligible, reduces appearance of phage-resistant bacteria to statistical negligibility. Normal human microbial flora species were not affected. In alternative embodiments of the method and the composition, antibiotic agents or other treatment agents can be administered with a cocktail of the plurality of bacteriophage strains.
A composition for preventing or reducing a Vibrio cholerae bacterial infection in a human subject, the composition comprising:
2-3. (canceled)
The composition according to claim 3, wherein the plurality comprises bacteriophage strains ICP-1, ICP-2, and ICP-3.
(canceled)
8-9. (canceled)
13-16. (canceled)
(canceled)
A method of preventing or ameliorating a Vibrio cholerae infection in a human subject, the method comprising:
20-21. (canceled)
The method according to claim 21 wherein the subject is selected from a household member or a family member of a patient, and doctor, a nurse, a medical work, and an orderly.
(canceled)
26-27. (canceled)
30-38. (canceled)
A kit comprising, a composition having a plurality of lytic bacteriophage strains selected from the group ICP-1, and ICP-3 specific for infection of cells of Vibrio cholera, the composition in a unit dose.
40-41. (canceled)
Dependencies are inferred from the claim text.