Preparation of platelet pellet lysate and its use for treating neurological disorders
AssigneesCentre Hospitaler Regional Et Universitaire De Lille (Chru), Universite De Lille 2 Droit Et Sante, Universite Du Littoral Cote D'Opale, Inserm (Institut National De La Sante Et De La Recherche Medicale), Taipei Medical University
InventorsDavid DEVOS, Thierry BURNOUF, Jean-christophe DEVEDJIAN, Ming-Li CHOU
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Abstract
A process for preparing a modified heat-treated platelet pellet lysate, said process comprising the steps of: a) Providing a platelet pellet lysate, b) Heat-treating the platelet pellet lysate at a temperature of 55° C. to 65° C. during 20 to 40 minutes, c) Purifying the heat-treated platelet pellet lysate of step b) so as to obtain a modified heat treated platelet pellet lysate having a total protein content of less than 70% of the total protein content of the platelet pellet lysate of step a).
Claims17
A process for preparing a modified heat-treated platelet pellet lysate, said process comprising the steps of:
- a) providing a platelet pellet lysate;
- b) heat-treating the platelet pellet lysate at a temperature of 55° C. to 65° C. during 20 to 40 minutesl and
- e) purifying the heat-treated platelet pellet lysate of step b) so as to obtain a modified heat treated platelet pellet lysate having a total protein content of less than 70% of the total protein content of the platelet pellet lysate of step a).
The process according to claim:
- 1, wherein the purification of step c) is carried out by centrifugation or filtration.
The process according to claim i, wherein the heat-treatment in step b) is pert armed at a temperature of 55° C. to 60° C. more preferably, at a temperature of about 56° C.
A modified heat-treated platelet pellet lysate, said lysate having a total protein content of less than 70%, less than 60%, more preferably less than 50% of the total protein content of non heat-treated platelet pellet lysate.
Dependencies are inferred from the claim text.