Antibacterial Use of Halogenated Salicylanilides
AssigneeUNION therapeutics A/S
InventorsEmilie Flora Aurore DELAVENNE, Daniel Jean Jacques SIMON, Morten Otto Alexander SOMMER, Rasmus Vendler TOFT-KEHLER
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Abstract
The invention relates to a halogenated salicylanilide selected from closantel, rafoxanide, oxyclozanide and niclosamide and derivatives thereof including salts, hydrates, esters and the like for use in the topical treatment or prevention of infections caused by Gram-positive bacteria such as Staphylococcus, in particular Staphylococcus aureus, and Streptococcus, in particular Streptococcus pyogenes. Grain positive bacteria treated with the halogenated salicylanilides exhibit a very low frequency of appearance of resistant mutants compared to commonly used topical antibiotics.
Claims46
-61. (canceled)
A method of treating a disease or infection caused by gram-positive bacteria in a subject, the method comprising topically administering to the subject an effective amount of oxyclozanide;
- wherein the Gram-positive bacteria is not a propionibacteria.
A method of treating or preventing pyoderma in a non-human animal, the method comprising topically administering to the subject an effective amount of oxyclozanide.
A method of treating or preventing a disease or infection caused by gram-positive bacteria in a subject, the method comprising topically administering to the subject an effective amount of oxyclozanide;
- wherein the Gram-positive bacteria is an antibiotic resistant strain.
A method of treating, preventing or eliminating bacterial colonization by gram-positive bacteria in a subject, the method comprising topically administering to the subject an effective amount of oxyclozanide.
A method of treating atopic dermatitis colonized by gram-positive bacteria in a subject, the method comprising topically administering to the subject an effective amount of oxyclozanide.
Dependencies are inferred from the claim text.