High Dosage Strength Tablets of Rucaparib

A tablet comprising the active pharmaceutical ingredient compound 8-fluoro-2-{4-[(methylamino) methyl] phenyl}-1, 3, 4, 5-tetrahydro-6H-azepino [5,4,3-cd] indol-6-one camsylate, wherein said compound is present in an amount that the tablet contains at least about 200 mg of 8-fluoro-2-{4-[(methylamino) methyl] phenyl}-1, 3, 4, 5-tetrahydro-6H-azepino [5,4,3-cd] indol-6-one, wherein at least 95% w/w of the active pharmaceutical ingredient is released within 60 min, when tested in 0.01N HCl according to USP II Paddles and at 75 rpm.

A tablet comprising the active pharmaceutical ingredient 8-fluoro-2-{4-[(methylamino) methyl] phenyl}-1, 3, 4, 5-tetrahydro-6H-azepino [5,4,3-cd] indol-6-one camsylate, wherein said compound is present in an amount that the tablet contains at least about 200 mg of 8-fluoro-2-{4-[(methylamino) methyl] phenyl}-1, 3, 4, 5-tetrahydro-6H-azepino [5,4,3-cd] indol-6-one, wherein the tablet can be compressed to a tensile strength of at least 2 MPa at a compression stress less than 250 MPa.