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US 2019/0099417 A1Published application
Abuse resistant drug formulation
AssigneeCima Labs Inc.
InventorsWalid A. Habib, Ehab Hamed, Manuel A. Vega Zepeda
Life of this patent
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Abstract
A pharmaceutical composition may include a coated particulate which may include at least one active pharmaceutical ingredient, particularly one susceptible to abuse by an individual. The coated particles may include a fat/wax and have improved controlled release and/or crush resistance. Method of making these coated particulate and dosage forms therewith are also described.
Claims20
A pharmaceutical composition comprising:
- a solid granulate consisting of:
- an opioid or a salt thereof in an amount of about 1-80% by weight of the granulate;
- a first material that is a natural or synthetic starch, a natural or synthetic cellulose, an acrylic, a vinylic, or a resin;
- and
- a second material that is hydroxypropylmethylcellulose;
- and,
- a coating on the granulate;
- wherein the first material and second material together are provided in an amount from about 0.1 to about 90 percent by weight of the formulation.
5 more elements
An extended release particle, consisting of:
- an opioid or a salt thereof in an amount of about 1-80% by weight of the particle;
- a first material that is a natural or synthetic starch, a natural or synthetic cellulose, an acrylic, a vinylic, or a resin;
- and
- a second material that is hydroxypropylmethylcellulose;
- and,
- a coating on the particle;
- wherein the first material and second material together are provided in an amount from about 0.1 to about 90 percent by weight of the particle.
4 more elements
Dependencies are inferred from the claim text.