Methods for enhancing liver regeneration
AssigneeThe Trustees of the University of Pennsylvania
InventorsJoseph BAUR, Sarmistha MUKHERJEE
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Abstract
The invention includes methods, kits, and pharmaceutical compositions for enhancing liver regeneration in a mammal in need thereof, comprising administering a therapeutically effective amount of an agent that increases nicotinamide adenine dinucleotide (NAD) activity. The methods may include administering a therapeutically effective amount of an agent that increases nicotinamide adenine dinucleotide (NAD) activity and a sirtuin 1 (Sirt1) agonist. The agent that increases NAD activity may be a NAD precursor. The NAD precursor may include one or more of tryptophan, nicotinic acid, nicotinic acid riboside, nicotinamide riboside (NR), nicotinamide, NADP, and NAD itself and a pharmaceutically acceptable salt thereof.
Claims22
A method for enhancing liver regeneration in a mammal in need thereof, the method comprising administering a therapeutically effective amount of an agent that increases nicotinamide adenine dinucleotide (NAD) activity.
11-62. (canceled)
A kit for providing a method for enhancing liver regeneration in a mammal in need thereof, the kit comprising a therapeutically effective amount nicotinamide adenine dinucleotide (NAD) precursor or an inhibitor of NAD consumption in unit dosage form.
A pharmaceutical composition for enhancing liver regeneration in a mammal in need thereof comprising a therapeutically effective amount of a nicotinamide adenine dinucleotide (NAD) precursor or an inhibitor of NAD consumption, and a physiologically compatible carrier medium, wherein the inhibitor of NAD consumption is selected from the group consisting of a poly adp-ribose polymerase (PARP) inhibitor, a CD38 inhibitor, and a pharmaceutically acceptable salt thereof.
73-82. (canceled)
Dependencies are inferred from the claim text.