Medicine for improving state of pregnancy, and use thereof

A medicine for ameliorating pregnancy conditions, the medicine comprising a compound represented by the following General Formula (I) or a pharmaceutically acceptable salt thereof as an active ingredient:

• wherein each of the adjacent pairs of R1 with R2, R3 with R4, and R5 with R6 independently
• (a) represents two adjacent hydrogen atoms, or R2 may be an alkyl group, or
• (b) may form another bond between the carbon atoms to which the pair members are respectively bonded;
• R7 represents a hydrogen atom, a hydroxyl group, or a protected hydroxyl group, or may be bonded to an alkyl and together represent an oxo group;
• R8 and R9 each independently represent a hydrogen atom or a hydroxyl group;
• R10 represents a hydrogen atom, an alkyl group, an alkyl group substituted with one or more hydroxyl groups, an alkenyl group, an alkenyl group substituted with one or more hydroxyl groups, or an alkyl group substituted with an oxo group;
• X represents an oxo group, (a hydrogen atom, a hydroxyl group), (a hydrogen atom, a hydrogen atom), or a group represented by formula:
• —CH2O—;
• Y represents an oxo group, (a hydrogen atom, a hydroxyl group), (a hydrogen atom, a hydrogen atom), or a group represented by formula:
• N—NR11R12 or formula:
• N—OR13;
• R11 and R12 each independently represent a hydrogen atom, an alkyl group, an aryl group, or a tosyl group;
• R13, R14, R15, R16, R17, R18, R19, R22, and R23 each independently represent a hydrogen atom or an alkyl group;
• R24 represents a ring which can include one or more heteroatoms and may be substituted as desired;
• and
• n represents 1 or 2, and
• in addition to the meanings described above, Y, R10 and R23 may also be bonded together with the carbon atoms to which Y, R10 and R23 are bonded, and represent a heterocyclic group formed from a saturated or unsaturated 5-membered or 6-membered ring and containing a nitrogen atom, a sulfur atom, and/or an oxygen atom, and the heterocyclic group may be substituted with one or more groups selected from an alkyl group, a hydroxyl group, an alkyloxy group, a benzyl group, a group represented by formula:
• —CH2Se(C6H5), and an alkyl group substituted with one or more hydroxyl groups.