Analgesic compounds
AssigneeZeno Royalties & Milestones, LLC
InventorsKevin Duane Bunker, Deborah Helen Slee, Chad Daniel Hopkins, Joseph Robert Pinchman, Mehmet Kahraman, Peter Qinhua Huang
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Abstract
Disclosed herein are compounds of Formula (I), methods of synthesizing compounds of Formula (I), and methods of using compounds of Formula (I) as an analgesic.
Claims74
Use of an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, in the preparation of a medicine for ameliorating or treating pain or fever, wherein the compound of Formula (I) has the structure:
- wherein:
- B1 is an optionally substituted fused bicyclic heteroaryl;
- R1 is selected from the group consisting of H, D, an optionally substituted C1-6 alkyl and an optionally substituted C1-6 haloalkyl;
- R2 is H or C(═O)R2A;
- R2A is selected from the group consisting of H, D, an optionally substituted C1-30 alkyl, an optionally substituted C2-30 alkenyl, an optionally substituted C2-30 alkynyl, an optionally substituted C3-30 cycloalkyl, an optionally substituted C1-4 alkoxy and an optionally substituted C1-8 haloalkyl;
- each A1 is independently CR4R5;
- each R4 and each R5 are independently selected from the group consisting of H, D, halogen, an unsubstituted C1-8 alkyl and an unsubstituted C1-6 haloalkyl;
- and
- m is 0 or 1.
A method for reducing or at least partially preventing pain or fever comprising administering an effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the compound of Formula (I) has the structure:
- wherein:
- B1 is an optionally substituted fused bicyclic heteroaryl;
- R1 is selected from the group consisting of H, D, an optionally substituted C1-6 alkyl and an optionally substituted C1-6 haloalkyl;
- R2 is H or C(═O)R2A;
- R2A is selected from the group consisting of H, D, an optionally substituted C1-30 alkyl, an optionally substituted C2-30 alkenyl, an optionally substituted C2-30 alkynyl, an optionally substituted C3-30 cycloalkyl and an optionally substituted C1-8 haloalkyl;
- each A1 is independently CR4R5;
- each R4 and each R5 are independently selected from the group consisting of H, D, halogen, an unsubstituted C1-8 alkyl and an unsubstituted C1-6 haloalkyl;
- and
- m is 0 or 1.
The use or method of claim 21, wherein B1 is substituted with one or more substituents selected from the group consisting of:
- D, halogen, hydroxy, C1-4 alkoxy, C1-8 alkyl, C3-20 cycloalkyl, aryl, heteroaryl, heterocyclyl, C1-6 haloalkyl, cyano, C2-8 alkenyl, C2-8 alkynyl, C3-20 cycloalkenyl, aryl(alkyl), heteroaryl(alkyl), heterocyclyl(alkyl), acyl, thiocarbonyl, O-carbamyl, N-carbamyl, O-thiocarbamyl, N-thiocarbamyl, C-amido, N-amido, C-thioamido, N-thioamido, S-sulfonamido, N-sulfonamido, C-carboxy, O-carboxy, sulfenyl, sulfinyl, sulfonyl, haloalkoxy, an amino, a mono-substituted amino group and a di-substituted amino group, wherein each of the aforementioned substituents can be optionally substituted.
Dependencies are inferred from the claim text.