Inhibitor of inflammasome activation
AssigneeKracie Holdings, Ltd.
InventorsShimpei WATANABE, Ayako ARAI, Yuichi TAKAJO, Satoshi INAMASU, Satoshi YOMODA, Akiko OHNO, Yuko KITAHARA, Taisaku KANATANI
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Abstract
To provide a novel inflammasome inhibitor capable of inhibiting activation of inflammasome, the present inventors newly found that arctigenin reduces the amount of 1L-1β released and the amount of activated caspase-1 upon stimulation with ATP, palmitic acid, MSU and Poly(dA:dT) and thus has an effect of inhibiting inflammasome activation. The present invention provides an inhibitor of inflammasome activation that comprises arctigenin as an active ingredient.
Claims11
An inhibitor of inflammasome activation comprising arctigenin and/or arctiin as an active ingredient.
A composition for inhibiting inflammasome activation comprising arctigenin and/or arctiin as an active ingredient.
A food composition for inhibiting inflammasome activation comprising arctigenin and/or arctiin as an active ingredient.
A method for inhibiting inflammasome activation including administering arctigenin and/or arctiin to a subject.
An inhibitor of caspase-1 production comprising arctigenin and/or arctiin as an active ingredient.
Dependencies are inferred from the claim text.