Methods for inhibiting conversion of choline to trimethylamine (tma)

A method of inhibiting the conversion of choline to trimethylamine (TMA) and reducing TMAO level in an individual comprising administering to the individual a composition comprising a compound set forth in Formula (I):

• wherein:
• Y+=N+;
• n is 1, 2 or 3;
• R1 is selected from
• m is 0, 1 or 2;
• W is CH2 or O;
• R2, R3 are independently selected from C1-C4 alkyl, or bound together to form part of a ring system;
• R4 is H, C1-C4 alkyl, or is absent when the compound exists as a carboxylate ion;
• X− is a pharmaceutically acceptable anion;
• and including any acceptable salts and solvates thereof;
• wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline in the individual.

A method of improving a condition associated with the conversion of choline to trimethylamine (TMA) in an individual comprising administering to the individual a compound set forth in Formula (I):

• wherein:
• Y+=N+;
• n is 1, 2 or 3;
• R1 is selected from
• m is 0, 1 or 2;
• W is CH2 or O;
• R2, R3 are independently selected from C1-C4 alkyl, or bound together to form part of a ring system;
• R4 is H, C1-C4 alkyl, or is absent when the compound exists as a carboxylate ion;
• X− is a pharmaceutically acceptable anion;
• and including any acceptable salts and solvates thereof;
• wherein the compound is administered in an amount effective to treat or prevent the disease or condition associated with choline-related trimethylamine (TMA) in the individual.