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US 2019/0099379 A1Published application
Solid simethicone particles and dosage form thereof
AssigneeJohnson & Johnson Consumer Inc.
InventorsGerard P. McNally, Christopher Szymczak
Life of this patent
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Abstract
The present invention is directed to microencapsulated simethicone particles containing simethicone and a water soluble coating, wherein the simethicone is about 50% by weight of the particle.
Claims23
Microencapsulated simethicone particles comprising:
- simethicone and a water soluble coating,
- wherein the simethicone is at least about 50% by weight of the particle.
A method for making a microencapsulated simethicone particles comprising the steps of:
- (a) forming a water coating solution,
- (b) combining simethicone and the water soluble coating solution and forming an emulsion, and
- (c) spray drying the emulsion.
A method of making microencapsulated simethicone particles comprising the steps of:
- (a) preparing simethicone granules;
- (b) preparing a coating solution;
- and
- (c) coating the simethicone granules with the coating solution.
1 more element
A method of preparing microencapsulated simethicone particles comprising:
- (a) forming a complex coacervate of simethicone particles and hydrocolloids;
- (b) cooling the complex coacervate to a gel temperature at a pH of about 5 to deposit a protein shell around each of the simethicone particles;
- (c) further cooling the complex coacervate to a cross-linking temperature below the gel temperature at a pH of about 7 to stabilize the protein shell;
- and
- (d) adding an enzyme to the water for enzymatically cross-linking the stabilized protein shell at about pH 7 to form microencapsulated simethicone particles.
2 more elements
Dependencies are inferred from the claim text.