Chewable dosage forms containing sitagliptin and metformin
AssigneeMerck Sharp & Dohme Corp.
InventorsWycliffe S. Omwancha, Rubi Burlage
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Abstract
The present invention provides a chewable dosage form having a matrix comprising: a combination of active pharmaceutical ingredients which is metformin hydrochloride and sitagliptin or a pharmaceutically acceptable salt thereof; a fully or partially pregelatinized starch, a polyethylene glycol polymer; a lubricant; an emulsifier; a flavoring agent; and a sweetener. The present invention also provides a method of treating diabetes, e.g., non-insulin dependent (Type 2) diabetes mellitus, comprising administering a therapeutically effective amount of the chewable dosage form to a mammalian patient in need thereof.
Claims17
A chewable dosage form having a matrix comprising:
- a combination of active pharmaceutical ingredients which is metformin hydrochloride and sitagliptin or a pharmaceutically acceptable salt thereof;
- a fully or partially pregelatinized starch;
- a polyethylene glycol polymer;
- a lubricant;
- an emulsifier;
- a flavoring agent;
- and
- a sweetener.
(canceled)
Dependencies are inferred from the claim text.