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US 2019/0099101 A1Published application
Methods and magnetic imaging devices to inventory human brain cortical function
AssigneeBrainn F.I.T. Imaging, LLC
InventorsJohn P. Ford, Gustavo P. Sudre
Life of this patent
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Abstract
Techniques are described for determining cognitive impairment, an example of which includes accessing a set of epochs of magnetoencephalography (MEG) data of responses of a brain of a test patient to a plurality of auditory stimulus events; processing the set of epochs to identify parameter values one or more of which is based on information from the individual epochs without averaging or otherwise collapsing the epoch data. The parameter values are input into a model that is trained based on the parameters to determine whether the test patient is cognitively impaired.
Claims45
A method comprising:
- accessing a set of epochs of magnetoencephalography (MEG) data of responses of a brain of a test patient to a plurality of auditory stimulus events;
- determining a plurality of parameter values by analyzing the individual epochs of the MEG data,
- at least one of the parameter values determined based on epochs captured by an MEG sensor located ipsilateral to the auditory stimulus events;
- and
- at least one of the parameter values determined based on epochs captured by an additional MEG sensor located contralateral to the auditory stimulus events;
- inputting the parameter values into a model that is trained based on the parameters to determine whether the test patient is cognitively impaired;
- and
- providing the determination.
5 more elements
A method of treating a patient having cognitive impairment, the method comprising:
- administering a therapeutically effective amount of an anti-cognitive impairment therapeutic agent to a patient who has been determined to have cognitive impairment,
- wherein the determination was made by a method comprising
- accessing a set of epochs of magnetoencephalography (MEG) data of responses of a brain of a test patient to a plurality of auditory stimulus events;
- determining a plurality of parameter values by analyzing the individual epochs of the MEG data,
- at least one of the parameter values determined based on epochs captured by an MEG sensor located ipsilateral to the auditory stimulus events;
- and
- at least one of the parameter values determined based on epochs captured by an additional MEG sensor located contralateral to the auditory stimulus events;
- inputting the parameter values into a model that is trained based on the parameters to determine whether the test patient is cognitively impaired;
- and
- providing the determination.
7 more elements
A method of setting the dosage of an anti-cognitive impairment therapeutic agent in a patient having cognitive impairment, comprising:
- accessing a set of epochs of magnetoencephalography (MEG) data of responses of a brain of a test patient to a plurality of auditory stimulus events;
- determining a plurality of parameter values by analyzing the individual epochs of the MEG data,
- at least one of the parameter values determined based on epochs captured by an MEG sensor located ipsilateral to the auditory stimulus events;
- and
- at least one of the parameter values determined based on epochs captured by an additional MEG sensor located contralateral to the auditory stimulus events;
- inputting the parameter values into a model that is trained based on the parameters to determine whether the test patient is cognitively impaired;
- and
- providing the determination as to degree of cognitive impairment;
- and
- setting the dosage of the anti-cognitive impairment therapeutic agent based on the determined degree of the patient's cognitive impairment.
7 more elements
A method of titrating the dosage of an anti-cognitive impairment therapeutic agent in a patient having cognitive impairment, comprising:
- performing a first determination and a second determination of the degree of cognitive impairment at a spaced interval during which interval the patient has been receiving an anti-cognitive impairment therapeutic agent at a first dosage level;
- and
- increasing the dose of the anti-cognitive impairment therapeutic agent to a second dosage level if the degree of cognitive impairment has increased between the first and second determinations,
- wherein each of the first and second determinations is made by
- accessing a set of epochs of magnetoencephalography (MEG) data of responses of a brain of a test patient to a plurality of auditory stimulus events;
- determining a plurality of parameter values by analyzing the individual epochs of the MEG data,
- at least one of the parameter values determined based on epochs captured by an MEG sensor located ipsilateral to the auditory stimulus events;
- and
- at least one of the parameter values determined based on epochs captured by an additional MEG sensor located contralateral to the auditory stimulus events;
- inputting the parameter values into a model that is trained based on the parameters to determine whether the test patient is cognitively impaired;
- and
- providing the determination.
9 more elements
A computer system comprising:
- a computer processor;
- a memory storing a set of instructions that when executed by the computer processor causes the computer processor to:
- access a set of epochs of magnetoencephalography (MEG) data of responses of a brain of a test patient to a plurality of auditory stimulus events;
- determine a plurality of parameter values by analyzing the individual epochs of the MEG data,
- at least one of the parameter values determined based on epochs captured by an MEG sensor located ipsilateral to the auditory stimulus events;
- and
- at least one of the parameter values determined based on epochs captured by an additional MEG sensor located contralateral to the auditory stimulus events;
- input the parameter values into a model that is trained based on the parameters to determine whether the test patient is cognitively impaired;
- and
- provide the determination.
7 more elements
Dependencies are inferred from the claim text.