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US 2019/0094205 A1Published application
Method for disease diagnosis based on metabolite in urine
AssigneeHitachi, Ltd.
InventorMinoru Sakairi
Life of this patent
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Abstract
The present invention relates to a method, a device, and a kit for detecting a cancer, predicting a cancer risk, determining a cancer stage, determining a cancer prognosis, and/or evaluating the effectiveness of a treatment in a subject by measuring a urinary metabolite in the subject, and a method for testing a cancer.
Claims17
A method for evaluating a cancer, comprising:
- measuring a urinary metabolite in a urine sample derived from a subject;
- and
- evaluating a cancer in the subject based on the measurement results,
- wherein the urinary metabolite comprises a metabolite which is measured to have a mass of 134.11 in the positive ion detection mode of liquid chromatography-mass spectrometry (LC/MS).
1 more element
A method for evaluating the effectiveness of a treatment on a cancer, comprising:
- measuring a urinary metabolite in a urine sample from an animal having a cancer and having received a treatment with a test therapeutic agent or a test therapeutic method;
- and
- evaluating the effectiveness of the test therapeutic agent or the test therapeutic method on a cancer based on the measurement results,
- wherein the urinary metabolite comprises a metabolite which is measured to have a mass of 134.11 in the positive ion detection mode of liquid chromatography-mass spectrometry (LC/MS).
1 more element
A device for evaluating a cancer, comprising:
- a measurement section which is configured to measure a urinary metabolite in a urine sample;
- a comparison section which is configured to compare the measured value of the urinary metabolite measured by the measurement section with a reference or a previously measured value;
- and
- a determination section which is configured to evaluate a cancer based on the comparison results obtained by the comparison section,
- wherein the urinary metabolite comprises a metabolite which is measured to have a mass of 134.11 in the positive ion detection mode of liquid chromatography-mass spectrometry (LC/MS).
2 more elements
A method for testing a cancer, comprising:
- receiving an input of the selection of a urinary metabolite to be used in a test as a primary test or the number of urinary metabolites;
- performing a multivariate analysis of the measured value in a urine sample derived from a test subject with respect to the input urinary metabolite or the input number of urinary metabolites;
- storing test results of the multivariate analysis;
- and
- a step of outputting the test results as primary test results,
- wherein in the selection of the urinary metabolite or the number thereof, the selection is performed from 2 types, 3 types, 4 to 8 types, 9 to 19 types, or 20 to 30 types of urinary metabolites comprising at least a metabolite which is measured to have a mass of 134.11 in the positive ion detection mode of liquid chromatography-mass spectrometry (LC/MS).
3 more elements
Dependencies are inferred from the claim text.