Molecular sensors and related methods
AssigneeSemiconBio Inc.
InventorsBarry L. Merriman, Paul W. Mola, Chulmin Choi
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Abstract
Electronic sensors configured to detect single molecules and DNA methods of using and manufacturing same are disclosed. A sensor may include source and drain electrodes spaced apart by a sensor gap; a gate electrode, wherein the source, drain and gate electrodes cooperate to form an electrode circuit; and a bridge molecule bridging across the sensor gap, connecting source and drain electrodes; and a probe coupled to the bridge molecule, wherein interaction of the probe with a nucleic acid is detectable by monitoring a parameter of the electrode circuit. In various examples, the nucleic acid comprises DNA or RNA.
Claims13
A sensor comprising:
- a source electrode;
- a drain electrode spaced apart from the source electrode by a sensor gap;
- a gate electrode, wherein the source, drain and gate electrodes cooperate to form an electrode circuit;
- and
- a bridge molecule bridging across said sensor gap, connecting the source and drain electrodes;
- and
- a probe coupled to the bridge molecule,
- wherein interaction of the probe with a nucleic acid is detectable by monitoring at least one parameter of the electrode circuit.
A sensor comprising:
- a first electrode overlying a substrate surface;
- a second electrode overlying the substrate surface;
- a sensor gap defined between the first electrode and the second electrode;
- and
- a bridge molecule comprising a first end and a second end;
- wherein the sensor gap comprises a sensor gap dimension of between about 5 nm and about 30 nm;
- and wherein the bridge molecule is coupled to the first contact at the first end and coupled to the second contact at the second end.
Dependencies are inferred from the claim text.