Debye length modulation
AssigneeFextoDx
InventorsPritiraj Mohanty, Shyamsunder Erramilli
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Abstract
Systems and methods for detection of biological agents are generally described. Target biological agents may be detected by use of a sensor, which in some situations is a nanowire. An external electric field is applied in some embodiments to induce an electric dipole. The induced electric dipole is detected, allowing detection of the biological agent.
Claims49
A device for sensing a chemical and/or biological analyte, comprising:
- a nanosensor, wherein at least a portion of the nanosensor is functionalized with a chemical and/or biological detector species;
- and
- a source of an alternating electric field, wherein the source is configured such that the electric field produced by the source is incident upon the nanosensor.
A method of sensing a chemical and/or biological analyte, comprising:
- applying an alternating electric field to a nanosensor functionalized with a chemical and/or biological detector species such that the Debye length of an analyte associated with the chemical and/or biological detector species is altered.
A method of sensing a chemical and/or biological analyte, comprising:
- applying an alternating electric field to a nanosensor functionalized with a chemical and/or biological detector species in the presence of a sample comprising an analyte;
- applying an electrical potential across the nanosensor;
- collecting a first set of data, based on the applied electrical potential, at points in time at which the alternating electric field is at a first power to provide a background signal;
- and
- collecting a second set of data, based on the applied electrical potential, at points in time at which the alternating electric field is at a second power that is different from the first power to provide a signal indicative of a property of the analyte, the detector species, and/or an interaction between the analyte and the detector species.
A method of sensing a chemical and/or biological analyte, comprising:
- applying an electrical potential across a nanosensor functionalized with a chemical and/or biological detector species in the presence of a sample comprising an analyte;
- and
- simultaneously collecting a first set of data to provide a background signal and a second set of data to provide a signal indicative of a property of the analyte, the detector species, and/or an interaction between the analyte and the detector species.
A method of detecting a biomolecule in an ionic fluid, the biomolecule having a charge, the method comprising:
- inducing a dipole electric field from the biomolecule and the ionic fluid by applying an electric field to the ionic fluid;
- and
- detecting a current and/or voltage of a sensor in response to inducing the dipole electric field.
Dependencies are inferred from the claim text.