Drimenol synthases iii
AssigneeFirmenich SA
InventorsEric Wen-Bo LIU, Xiu-Feng HE, Olivier HAEFLIGER, Zong-Xia YU, Pan LI
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Abstract
The present invention discloses a method of producing drimenol and/or drimenol derivatives by contacting a polypeptide with farnesyl pyrophosphate. Also provided is an amino acid sequence of a polypeptide useful in the methods of the invention and nucleic acid encoding the polypeptides of the invention. The method further provides host cells or organisms genetically modified to express the polypeptides of the invention and useful to produce drimenol and/or drimenol derivatives.
Claims18
A method of producing drimenol comprising:
- i) contacting an acyclic farnesyl diphosphate (FPP) precursor with a polypeptide having drimenol synthase activity and having at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98% or 99% sequence identity to SEQ ID NO:
- 2 or comprising SEQ ID NO:2 to produce drimenol;
- and
- ii) optionally isolating the drimenol.
The isolated polypeptide having drimenol synthase activity of claim 6 comprising the amino acid sequence of SEQ ID NO:
- 2.
An isolated polypeptide having drimenol synthase activity comprising an amino acid sequence having at least 90%, 95%, 96%, 97%, 98% or 99% sequence identity to SEQ ID NO:
- 2.
Dependencies are inferred from the claim text.