High density lipoprotein functionalized magnetic nanostructures
AssigneeNorthwestern University
InventorsVikas Nandwana, Soo-Ryoon Ryoo, Vinayak Dravid, C. Shad Thaxton
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Abstract
Provided herein are compositions and methods for diagnosis and treatment of early-stage atherosclerotic plaques and reduction of plaques in arteries. In particular, provided herein are high-density-lipoprotein-functionalized magnetic nanostructures (HDL-MNS) capable of (i) precise anatomic detection of atherosclerotic lesions, (ii) removal of excess cholesterol from macrophage cells in atherosclerotic plaque, and/or (iii) delivery of therapeutic agents to plaque locations, and methods of diagnosis and treatment of atherosclerosis.
Claims20
A high density lipoprotein magnetic nanostructure (HDL-MNS) particle, the particle comprising:
- (a) a magnetic core having a surface;
- (b) a hydrophilic layer comprising hydrophilic compounds on the surface of the magnetic core;
- (c) HDL-based proteins surrounding the hydrophilic layer;
- and
- (d) a lipid layer surrounding the HDL-based proteins.
Dependencies are inferred from the claim text.