Adaptive range titration systems and methods
AssigneeEcolab USA Inc.
InventorsRobert J. Ryther, Paul R. Kraus
Life of this patent
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Abstract
Systems for quantifying a target analyte concentration in a process solution are provided and can be used, for example, in methods for quantifying a target analyte concentration. These systems and methods include continuous automated titration methods that use titration chemistries to measure the target analyte concentration in the process solution. The method steps provide for efficient and robust automated titration methods for a variety of target analytes and can include methods that provide for methods that provide a dynamic range for measurement of target analyte concentrations.
Claims22
An automated titration system comprising
- a reaction manifold for mixing a continuously flowing and refreshed sample stream containing an unknown concentration of an analyte with titrant;
- a sample pump for pumping the continuously flowing and refreshed sample stream into the reaction manifold;
- a titrant pump for pumping the titrant into the reaction manifold to contact the continuously flowing and refreshed sample stream;
- a detector for detecting a titration endpoint of the reaction between the analyte and the titrant;
- and
- a controller communicatively coupled to the sample pump, the titrant pump, and the detector,
- wherein the controller controls the sample pump to set the flow rate of the continuously flowing and refreshed sample stream, controls the titrant pump to set the flow rate of the titrant, and receives data from the detector to detect a titration endpoint for the reaction between the analyte and the titrant and determine the analyte concentration.
A method for quantification of a target analyte concentration in a sample stream comprising:
- continuously flowing and continuously refreshing the sample stream at a variable flow rate through an analyzer comprising a manifold and a detector;
- quantifying the target analyte concentration by continuously adding a titrant to the analyzer and setting a titrant concentration change by changing the titrant concentration through increasing or decreasing a flow rate of the titrant over a specified range;
- and
- detecting a titration endpoint for the reaction between the target analyte and the titrant within a specified target analyte concentration range.
-22 (canceled)
-36. (canceled)
Dependencies are inferred from the claim text.