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US 2019/0084941 A1Published application
Compounds and methods of treating infections
AssigneeNeoculi Pty Ltd
InventorsStephen Page, Sanjay Garg, Martine Keenan, Adam McCluskey, Andrew Stevens
Life of this patent
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Abstract
The invention provides compounds of Formula I, and methods of treating or preventing a bacterial infection in a subject using a compound of Formula I. The invention also provides the use of a compound of Formula I in the manufacture of a medicament for the treatment of a bacterial infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a bacterial infection in a subject and to a medical device comprising the composition of the invention.
Claims5
-48. (canceled)
A compound selected from the group consisting of:
- NCL178 4,6-bis(2-((E)-1-(4-chlorophenyl)ethylidene)hydrazinyl)pyrimidine
- NCL179 4,6-bis(2-((E)-4-chlorobenzylidene)hydrazinyl)pyrimidin-2-amine
- NCL180 (2Z,2′Z)-2,2′-(pyrimidine-4,6-diylbis(hydrazin-2-yl-1-ylidene))bis(2-(4-chlorophenyl)ethan-1-ol)
- NCL 181 4,6-bis(2-((E)-4-chlorobenzylidene)hydrazinyl)pyrimidine
- NCL183 N4,N6-bis(1-phenylethyl)pyrimidine-4,6-diamine
- NCL184 N4,N6-bis(1-phenylethyl)pyrimidine-2,4,6-triamine
- NCL185 4,6-bis(2-((E)-1-(4-chlorophenyl)ethylidene)hydrazinyl)pyrimidinehydrochloride
- NCL 187 4,6-bis(2-((E)-4-chlorobenzylidene)hydrazinyl)pyrimidinehydrochloride
- NCL189 (2Z,2′Z)-2,2′-(pyrimidine-4,6-diylbis(hydrazin-2-yl-1-ylidene))bis(2-(4-chlorophenyl)ethan-1-ol)hydrochloride
- NCL193 4,6-bis(2-((E)-4-bromobenzylidene)hydrazinyl)pyrimidin-2-amine
- NCL194 N′,N′″-(2-aminopyrimidine-4,6-diyl)di(benzohydrazide)
- NCL195 4,6-bis(2-((E)-4-methylbenzylidene)hydrazinyl)pyrimidin-2-amine
- NCL 196 4,4′-((1E,1′E)-((2-aminopyrimidine-4,6-diyl)bis(hydrazin-2-yl-1-ylidene))bis(methanylylidene))diphenol
- NCL197 3,3′-((1E,1′E)-((2-aminopyrimidine-4,6-diyl)bis(hydrazin-2-yl-1-ylidene))bis(methanylylidene))diphenol
- NCL198 4,6-bis(2-((E)-4-(tert-butyl)benzylidene)hydrazinyl)pyrimidin-2-aminedihydrochloride
- NCL199 4,6-bis(2-((E)-benzylidene)hydrazinyl)pyrimidin-2-amine
- NCL200 4,6-bis(2-((E)-4-(tert-butyl)benzylidene)hydrazinyl)pyrimidin-2-amine
- NCL201 4,4′-((1E,1′E)-((2-aminopyrimidine-4,6-diyl)bis(hydrazin-2-yl-1-ylidene))bis(methanylylidene))bis(N,N-dimethylaniline)
- NCL202 2,2′-((1E,1′E)-((2-aminopyrimidine-4,6-diyl)bis(hydrazin-2-yl-1-ylidene))bis(methanylylidene))diphenol
- NCL203 4,6-bis(2-((E)-cyclohexylmethylene)hydrazinyl)pyrimidin-2-aminedihydrochloride
- NCL204 4,6-bis(2-((E)-1-(4-chlorophenyl)ethylidene)hydrazinyl)pyrimidin-2-amine
- NCL205 4,6-bis(2-((E)-2-chlorobenzylidene)hydrazinyl)pyrimidin-2-amine
- NCL206 4,6-bis(2-((E)-4-methylbenzylidene)hydrazinyl)-1,3,5-triazin-2-amine
- NCL207 2,2′-((1E,1′E)-((6-amino-1,3,5-triazine-2,4-diyl)bis(hydrazin-2-yl-1-ylidene))bis(methanylylidene))diphenol
- NCL208 4,6-bis(2-((E)-1-(4-chlorophenyl)ethylidene)hydrazinyl)-1,3,5-triazin-2-amine
- NCL209 3,3′-((1E,1′E)-((6-amino-1,3,5-triazine-2,4-diyl)bis(hydrazin-2-yl-1-ylidene))bis(methanylylidene))diphenol
- NCL210 4,6-bis(2-((E)-4-(trifluoromethyl)benzylidene)hydrazinyl)-1,3,5-triazin-2-amine
- NCL211 4,4′-((1E,1′E)-((6-amino-1,3,5-triazine-2,4-diyl)bis(hydrazin-2-yl-1-ylidene))bis(methanylylidene))diphenol
- NCL212 4,6-bis(2-((E)-4-bromobenzylidene)hydrazinyl)-1,3,5-triazin-2-amine
- NCL213 4,6-bis(2-((E)-cyclohexylmethylene)hydrazinyl)-1,3,5-triazin-2-amine
- NCL218 4-((E)-(2-(2-amino-6-(2-((E)-4-((diethoxyphosphoryl)oxy)benzylidene)hydrazinyl)pyrimidin-4-yl)hydrazono)methyl)phenyldiethylphosphate
- NCL220 4,6-bis(2-((E)-4-fluorobenzylidene)hydrazinyl)pyrimidin-2-amine
- NCL221 4,6-bis(2-((E)-4-(trifluoromethyl)benzylidene)hydrazinyl)pyrimidin-2-amine
- NCL222 4,6-bis(2-((E)-3,4-difluorobenzylidene)hydrazinyl)pyrimidin-2-amine
- NCL223 N,N′-(((1E,1′E)-((2-aminopyrimidine-4,6-diyl)bis(hydrazin-2-yl-1-ylidene))bis(methanylylidene))bis(4,1-phenylene))diacetamide
- NCL230 4,6-bis(2-((E)-4-methoxybenzylidene)hydrazinyl)pyrimidin-2-amine
33 more elements
Dependencies are inferred from the claim text.