Hendra and nipah virus g glycoprotein immunogenic compositions
AssigneeZoetis Services LLC
InventorsJohn M. Hardham, Jin-An Huang, Paul J. Dominowski
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Abstract
This invention relates to Hendra virus and Nipah virus immunogenic compositions and methods of use. The invention further relates to immunogenic compositions comprising Hendra virus G glycoprotein, and methods of protecting against Nipah virus infection and disease. The invention also relates to methods of distinguishing subjects vaccinated with the immunogenic compositions of the invention from those infected with Hendra and/or Nipah virus.
Claims20
An immunogenic composition comprising Hendra virus G glycoprotein, an adjuvant formulation, and one or more excipients, in an amount effective to elicit production of neutralizing antibodies against Nipah virus following administration to a subject, wherein said adjuvant formulation comprises a saponin, a sterol, a quaternary ammonium compound, a polyacrylic acid polymer, and a glycolipid.
Dependencies are inferred from the claim text.