Immunogenic composition
AssigneeGlaxosmithkline Biologicals SA
InventorsChristiane Marie-Paule Simon Jeanne FERON, Sandra GIANNINI
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Abstract
The present invention discloses a recombinant bacteriophage comprising a phage genome polynucleotide including a gene encoding a heterologous antigen protein(s) and a killing gene encoding a protein that is capable of killing a host bacterium. Such a recombinant bacteriophage is designed to prime a subject's immune response and to kill the bacterium that it infects such that the “prime and kill” bacteriophage provides two lines of protection against infectious disease.
Claims17
1-69. (canceled)
A recombinant bacteriophage comprising a phage genome polynucleotide including a gene encoding a heterologous antigen protein(s) and a killing gene encoding a protein that is capable of killing a host bacterium wherein following entry of the recombinant bacteriophage into a host bacterium, expression of the heterologous antigen protein is driven by a promoter allowing the heterologous antigen to be released from the host bacterium and the heterologous antigen protein(s) is not expressed as part of a phage coat/capsid protein.
A recombinant bacteriophage genome polynucleotide comprising a heterologous antigen gene encoding a heterologous antigen protein and a killing gene encoding a protein that is capable of killing a host bacterium wherein the heterologous antigen protein, after expression is released into the cytoplasm of a bacterium infected by the bacteriophage.
Dependencies are inferred from the claim text.