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US 2019/0060485 A1Published application
Materials and methods for effective in vivo delivery of dna nanostructures to atherosclerotic plaques
AssigneeThe Chinese University of Hong Kong
InventorsCHUNG HANG JONATHAN CHOI, LEI ZHANG
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Abstract
Provided are DNA-coated nanoparticles (DNA-NPS), superparamagnetic nanoparticles (DNA-SPNs), and superparamagnetic iron oxide nanoparticles (DNA-SPIONs) as efficient imaging agents for targeting and imaging atherosclerotic lesions and treating atherosclerotic disease. The DNA-NS, DNA-SPNs, and DNA-SPIONs can enter macrophage cells via the Class A scavenger receptor (SR-A)-mediated pathways and can be used to specifically target atheroscleortic plaques.
Claims22
A nanoparticle (NP)-cored spherical nucleic acid (DNA-NP) comprising poly(ethylenglycol) (PEG)-linked oligonucleotides.
Dependencies are inferred from the claim text.