Methods, systems, and apparatus for optimizing effects of treatment with medication using medication compliance patterns

A method of optimizing treatment of a medication recipient patient, comprising:

• providing the patient with a reprogrammable medication monitor capable of providing usage data regarding the patient's compliance with a medication treatment regimen, the treatment regimen being established based on a medication compliance pattern of the patient, wherein the compliance pattern is a statistical pattern derived from a plurality of data points gathered over a period of time of not less than one week, where the data points include doses missed, doses taken early, doses taken late, and taken on time,
• the medication monitor including:
• a housing body that includes a housing for containing medication or medication packaging, the housing body defining an opening to accommodate insertion and removal of the medication or of the medication packaging, and
• a removal sensor that senses at least one of (i) removal of the medication or of the medication packaging and (ii) opening of the housing body;
• collecting the usage data from the medication monitor at a central server over a predetermined period of time;
• determining the safety and efficacy of the treatment regimen;
• determining the patient's pattern of compliance with the treatment regimen based on the usage data collected from the medication monitor;
• obtaining diagnostic test results from a biomarker device, the diagnostic test results being indicative of a response of the patient to the treatment regimen over the predetermined period of time,
• the biomarker device being configured to be implanted in the patient or provided external to the patient;
• correlating the patient's pattern of compliance and diagnostic test results with patterns of compliance and diagnostic test results from a population of patients to obtain a correlation;
• outputting at least one recommendation based on the correlation and based on the safety and efficacy of the treatment regimen, the at least one recommendation selected from the group consisting of:
• replacing at least one medication used in the treatment regimen with at least one different medication,
• changing at least one dosage of at least one medication used in the treatment regimen, and
• changing the timing of recommended usage of at least one medication in the treatment regimen;
• and
• adjusting the treatment regimen of the patient based on the at least one recommendation.