Machine based classifier for genetic interactions

A non-transitory machine readable medium, including instructions, which when executed by a machine, cause the machine to perform the operations comprising:

• constructing a nucleic acid mutation interaction network based upon nucleic acid pair-level interactions of a genetic sample scored under at least one disease model;
• performing a thresholding and binarization process on the nucleic acid pair interactions to derive an interaction network;
• testing pairs of pathways of the interaction network for either between pathway model (BPM) or within pathway model (WPM) enrichment of nucleic acid-nucleic acid mutation pair interaction;
• and
• outputting nucleic acid-nucleic acid mutation pair interaction data.

A system comprising:

• a processor;
• and
• a memory, the memory including instructions, which when executed by a machine, cause the machine to perform the operations comprising:
• constructing a nucleic acid mutation interaction network based upon nucleic acid pair-level interactions of a genetic sample scored under at least one disease model;
• performing a thresholding and binarization process on the nucleic acid pair interactions to derive an interaction network:
• testing pairs of pathways of the interaction network for either between pathway model (BPM) or within pathway model (WPM) enrichment of nucleic acid-nucleic acid mutation pair interaction;
• and
• outputting nucleic acid-nucleic acid mutation pair interaction data.