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US 2019/0056402 A1Published application
Organ specific diagnostic panels and methods for identification of organ specific panel proteins
AssigneeBiodesix, Inc.
InventorsXiao-Jun Li, Paul Kearney
Life of this patent
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Abstract
The present application provides novel compositions, methods, and assays for use in identification of appropriate diagnostic markers in blood. These compositions, methods, and assays are capable of distinguishing normal levels of detectable markers from changes in marker levels that are indicative of changes in health status.
Claims7
A method for predicting a risk for development of a lung disease in a subject, comprising:
- determining the protein expression of a plurality of proteins comprising at least CLDN18, CPB2, WIF1, PPBP, and ALOX15B from a biological sample from the subject, wherein said determining step comprises ionizing CLDN18, CPB2, WIF1, PPBP, and ALOX15B;
- comparing the protein expression from step (a) to the protein expression of a plurality of proteins comprising at least CLDN18, CPB2, WIF1, PPBP, and ALOX15B from a control biological sample, wherein the control biological sample is obtained from a subject without lung disease;
- predicting that the subject is at risk of developing lung disease based on the differential protein expression of the plurality of proteins between the subject biological sample and the control biological sample, wherein the subject is at risk of developing lung disease if the differential protein expression it at least 10%.
Dependencies are inferred from the claim text.