Method for measuring the plasma concentration of an analyte directly on a whole blood sample
AssigneeBiomerieux
InventorsSylvie Cheucle, Laure Marillet, Aurélie Thollet
Life of this patent
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Abstract
A method of measuring an analyte amount in a whole blood sample, including (i) measuring the haematocrit level of the whole blood sample; (ii) measuring an analyte amount directly in the whole blood sample; and (iii) calculating a corrected analyte amount according to relation DP=Pa(DST,DH), where DP, is the corrected analyte amount, DST is the measured analyte amount, DH is the measured haematocrit level, and Pa is a non-constant polynomial of a degree greater than or equal to 1 having as indeterminate values the measured analyte amount, DST, and the measured haematocrit level, DH, and having its polynomial coefficients depending on the analyte.
Claims20
A method of measuring an amount of analyte in a whole blood sample, wherein the method comprises:
- measuring the haematocrit level of the whole blood sample;
- measuring an analyte amount directly in the whole blood sample;
- and
- calculating a corrected analyte amount according to relation:
- Dp=Pa(DST,DH)
- where DP is the corrected analyte amount, DST is the measured analyte amount, DH is the measured haematocrit level, and Pa is a non-constant polynomial of a degree greater than or equal to 1 having as indeterminate values the measured analyte amount, DST and the measured haematocrit level, DH, and having its polynomial coefficients depending on the analyte.
A method of measuring an analyte concentration in a whole blood sample, wherein the method comprises:
- measuring the haematocrit level of the whole blood sample;
- measuring an analyte amount directly in the whole blood sample and transforming the measured amount into a concentration by dividing the measured amount by the sample volume;
- and
- calculating a corrected analyte concentration according to relation:
- CP=Pa(CST,DH)
- where CP is the corrected analyte amount, CST is the measured analyte amount, DH is the measured haematocrit level, and Pa is a non-constant polynomial of a degree greater than or equal to 1 having as indeterminate values the measured analyte concentration, CST, and the measured haematocrit level, DH, and having its polynomial coefficients depending on the analyte.
A device for measuring the plasmatic amount of an analyte in a whole blood sample, wherein the device comprises
- means for receiving said whole blood sample;
- means for measuring the total analyte amount in the whole blood sample;
- means for calculating a corrected analyte amount according to relation:
- DP=Pa(DST,DH)
- where DP is the corrected analyte amount, DST is the measured analyte amount, DH is the measured haematocrit level, and Pa is a non-constant polynomial of a degree greater than or equal to 1 having as indeterminate values the measured analyte amount, DST, and the measured haematocrit level, DH, and having its polynomial coefficients depending on the analyte.
A device for measuring the plasmatic analyte concentration in a whole blood sample, wherein the device comprises
- means for receiving said whole blood sample;
- means for measuring the total analyte amount in the whole blood sample;
- means for transforming the analyte amount into a concentration;
- means for inputting or for measuring the haematocrit level in the whole blood sample;
- means for calculating a corrected analyte concentration according to relation:
- Cp=Pa(CST,DH)
- where CP is the corrected analyte concentration, CST is the analyte concentration calculated from the measured amount and from the sample volume, DH is the measured haematocrit level, and Pa is a non-constant polynomial of degree greater than or equal to 1 having as indeterminate values the analyte concentration obtained from the measured amount, CST, and the measured haematocrit level, DH, and having its polynomial coefficients depending on the analyte.
Dependencies are inferred from the claim text.