Methods for selectively separating samples from substrate
AssigneeSeoul National University R&Db Foundation
InventorsSunghoon KWON, Sungsik KIM, Yushin JUNG, Amos Chungwon LEE, Sangwook BAE, Jinhyun KIM
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Abstract
Provided is a method for selectively separating samples from a substrate. The method includes: providing a substrate mounted with samples; selecting one or more desired target areas from areas of a layer of the samples; patterning an energy source so as to correspond to the target areas; and extracting energy from the patterned energy source, applying the extracted energy to the target areas such that target samples corresponding to the target areas are released from the substrate, and recovering the target samples.
Claims23
A method for selectively separating samples from a substrate, comprising:
- providing a substrate mounted with samples;
- selecting one or more desired target areas from areas of a layer of the samples;
- patterning an energy source so as to correspond to the target areas;
- and extracting energy from the patterned energy source, applying the extracted energy to the target areas such that target samples corresponding to the target areas are released from the substrate, and recovering the target samples.
A method for selectively separating samples from a substrate, comprising:
- providing a substrate mounted with biological material samples;
- selecting one or more desired target areas from areas of a layer of the biological material samples;
- extracting light energy from a laser light source;
- modulating the shape of the extracted light so as to correspond to the shape of target samples corresponding to the target areas;
- applying a single shot of the light energy such that the shape-modulated light matches the target areas, to allow the target samples to be released from the substrate;
- and recovering the released target samples on a counterpart substrate.
An apparatus for selectively separating samples from a substrate, comprising:
- a stage adapted to support a substrate mounted with samples;
- a laser light source unit from which light is extracted to separate target samples from the samples;
- a light shape modulator adapted to pattern the laser light along the shape of target areas where the target samples are located;
- and a sample recovery stage on which a substrate is located to accommodate the separated target samples.
A method for selectively separating samples from a substrate, comprising:
- providing a substrate mounted with samples;
- selecting one or more desired target areas from areas of a layer of the samples;
- applying the extracted energy to the target areas such that target samples corresponding to the target areas are released from the substrate, and recovering the target samples,
- wherein the samples are biological materials, and
- the sample layer and the substrate are separated by a sacrificial layer composed of a material that is controlled to transfer energy sufficient to separate the target areas from the substrate without causing damage to the target areas when the energy is applied.
Dependencies are inferred from the claim text.