System and method for processing genotype information relating to drug metabolism
AssigneeProove Biosciences, Inc.
InventorBrian MESHKIN
Life of this patent
Estimating the term…
Abstract
There are systems and methods for preparing or using prognostic information about drug metabolism response. The information may include determining patient information, including DNA information, associated with a human subject; determining from the DNA information whether a subject genotype of the human subject includes one or more alleles or haplotypes in the one or more genes of the subject genotype by detecting, utilizing a detection technology and the DNA information, a presence or absence of the one or more alleles or haplotypes.
Claims20
A method comprising facilitating a processing of and/or processing (1) data and/or (2) information and/or (3) at least one signal, the (1) data and/or (2) information and/or (3) at least one signal based, at least in part, on the following:
- determining patient information, including DNA information, associated with a human subject;
- determining from the DNA information whether a subject genotype of the human subject includes one or more alleles or haplotypes in at least one gene by detecting, utilizing a detection technology and the DNA information, a presence or absence of the one or more alleles or haplotypes in the one or more genes of the subject genotype,
- wherein the at least one gene is selected from the gene group:
- CYP2C8, CYP2C9, CYP2C19, CYP3A4, CYP3A5, CYP2D6, CYP1A2, VKORC1, UGT2B7, UGT2B15, CYP2B6 and CYP2E1;
- determining at least one allele score associated with the alleles or haplotypes in the one or more genes based on the detected presence or absence of the one or more alleles or haplotypes in the one or more genes;
- determining at least one grade associated with one or more genes of the at least one gene based on the determined at least one allele score;
- and
- determining a drug metabolism response by the human subject associated with at least one drug based on the determined at least one grade associated with the one or more genes of the at least one gene.
An apparatus comprising:
- at least one processor;
- and
- at least one memory including computer program code for one or more programs,
- the at least one memory and the computer program code configured to, with the at least one processor, cause the apparatus to perform at least the following,
- determine patient information, including DNA information, associated with a human subject;
- determine from the DNA information whether a subject genotype of the human subject includes one or more alleles or haplotypes in at least one gene by detecting, utilizing a detection technology and the DNA information, a presence or absence of the one or more alleles or haplotypes in the one or more genes of the subject genotype,
- wherein the at least one gene is selected from the gene group:
- CYP2C8, CYP2C9, CYP2C19, CYP3A4, CYP3A5, CYP2D6, CYP1A2, VKORC1, UGT2B7, UGT2B15, CYP2B6 and CYP2E1;
- determine at least one allele score associated with the alleles or haplotypes in the one or more genes based on the detected presence or absence of the one or more alleles or haplotypes in the one or more genes;
- determine at least one grade associated with one or more genes of the at least one gene based on the determined at least one allele score;
- and
- determine a drug metabolism response by the human subject associated with at least one drug based on the determined at least one grade associated with the one or more genes of the at least one gene.
A non-transitory computer readable medium storing computer readable instructions that when executed by at least one processor perform a method, the method comprising facilitating a processing of and/or processing (1) data and/or (2) information and/or (3) at least one signal, the (1) data and/or (2) information and/or (3) at least one signal based, at least in part, on the following:
- determining patient information, including DNA information, associated with a human subject;
- determining from the DNA information whether a subject genotype of the human subject includes one or more alleles or haplotypes in at least one gene by detecting, utilizing a detection technology and the DNA information, a presence or absence of the one or more alleles or haplotypes in the one or more genes of the subject genotype,
- wherein the at least one gene is selected from the gene group:
- CYP2C8, CYP2C9, CYP2C19, CYP3A4, CYP3A5, CYP2D6, CYP1A2, VKORC1, UGT2B7, UGT2B15, CYP2B6 and CYP2E1;
- determining at least one allele score associated with the alleles or haplotypes in the one or more genes based on the detected presence or absence of the one or more alleles or haplotypes in the one or more genes;
- determining at least one grade associated with one or more genes of the at least one gene based on the determined at least one allele score;
- and
- determining a drug metabolism response by the human subject associated with at least one drug based on the determined at least one grade associated with the one or more genes of the at least one gene.
Dependencies are inferred from the claim text.