Back to results
US 2019/0055557 A1Published application
Compositions and Methods For Treating Cachexia
OwnerCarlo M. Croce, Denis C. Guttridgeinventors
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
OwnerCarlo M. Croce, Denis C. Guttridgeinventors
Estimating the term…
The present invention relates, in various embodiments, to methods of treating cachexia (e.g., cancer cachexia) in a patient. The methods comprise administering at least one compound for inhibiting, in alternative embodiments, the expression or activity of a microRNA that is present in microvesicles secreted from cancer cells in the patient (e.g., a miR-21 gene product), the expression or activity of a Toll-like receptor (e.g., TLR7, TLR8), the expression or activity of a c-Jun N-terminal kinase (JNK), the secretion of microvesicles from cancer cells, or the fusion of microvesicles from cancer cells with muscle cells or adipocytes. The present invention also relates, in certain embodiments, to pharmaceutical compositions comprising at least two compounds useful in the practice of the methods of the invention described herein.
A method of treating cachexia in a patient in need thereof, comprising administering to the patient an effective amount of at least one compound for inhibiting the expression or activity of a miR-21 gene product.
A method of treating cachexia in a patient in need thereof, comprising administering to the patient an effective amount of at least one compound for inhibiting the expression or activity of a Toll-like receptor 7 (TLR7 receptor) or a Toll-like receptor 8 (TLR8 receptor), at least one compound for inhibiting the expression or activity of a c-Jun N-terminal kinase (JNK), at least one compound for inhibiting secretion of microvesicles from cancer cells in the patient, at least one compound for inhibiting fusion of microvesicles from cancer cells with muscle cells or adipocytes in the patient, or at least one compound for inhibiting fusion of microvesicles from cancer cells with muscle cells or adipocytes in the patient.
A pharmaceutical composition comprising at least two compounds selected from the group consisting of a compound for inhibiting the expression or activity of a microRNA that is present in microvesicles secreted from cancer cells, compound for inhibiting the expression or activity of a Toll-like receptor 7 (TLR7 receptor) or a Toll-like receptor 8 (TLR8 receptor), a compound for inhibiting the expression or activity of a c-Jun N-terminal kinase (JNK), a compound for inhibiting secretion of microvesicles from cancer cells, and a compound for inhibiting fusion of microvesicles from cancer cells with muscle cells or adipocytes, or pharmaceutically-acceptable salts thereof.
Dependencies are inferred from the claim text.