Targeting pleiotrophin signaling to limit high-grade glioma invasion
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsMichelle Monje-Deisseroth, Elizabeth Qin
Life of this patent
Estimating the term…
Abstract
Compositions and methods for treatment of glioma are disclosed. In particular, the invention relates to methods of treating glioma by inhibiting pleiotrophin signaling to limit high-grade glioma invasion.
Claims26
A method of treating glioma comprising administering to a subject in need thereof a therapeutically effective amount of at least one inhibitory nucleic acid that inhibits expression of one or more genes selected from the group consisting of PTN, HSP90B, SPARC, SPARCL1, and PTPRZ.
A method of inhibiting glioma tropism towards a brain subventricular zone in response to a chemoattractant complex, the method comprising administering to a subject in need thereof at least one inhibitory nucleic acid that inhibits expression of one or more genes selected from the group consisting of PTN, HSP90B, SPARC, and SPARCL1, wherein said at least one inhibitory nucleic acid is administered in an amount sufficient to interfere with assembly of the chemoattractant complex in the brain subventricular zone.
Dependencies are inferred from the claim text.