Polynucleotide nanoparticles for the modulation of gene expression and uses thereof
AssigneeHalo-Bio Rnai Therapeutics, Inc.
InventorTodd M. HAUSER
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Abstract
The present invention is directed to novel self-forming polynucleotide nanoparticles, and the use of such nanoparticles and compositions comprising the same for gene modulation in a variety of organisms.
Claims20
An isolated polynucleotide nanoparticle approximately 40 nm diameter with at least twice the ratio of stems on the outer surface than at the center, comprising two or more connected MV-RNA sequences, each MV-RNA sequence separated by a linking element.
An isolated polynucleotide nanoparticle approximately 100 nm diameter with at least four times the ratio of stems on the outer surface than at the center, comprising stacked sets of three MV-RNA, wherein each stacked MV-RNA set is separated by a linking element.
Dependencies are inferred from the claim text.