Use of apoptotic cells ex vivo to generate regulatory t cells
AssigneeMallinckrodt Hospital Products IP Limited
InventorsDavid Peritt, Kim Campbell, Amy Krutsick
Life of this patent
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Abstract
Many cell types in the body can remove apoptotic and cellular debris from tissues; however, the professional phagocyte, or antigen presenting cell (“APC”), has a high capacity to do so. The recognition of apoptotic cells (“ACs”) occurs via a series of evolutionarily-conserved, AC associated molecular-pattern receptors (“ACAMPRs”) on APCs that recognize and bind corresponding apoptotic-cell-associated molecular patterns (“ACAMPs”). These receptors recognize ligands such as phosphotidyl serine and oxidized lipids found on apoptotic cells. Savill et al. (2002); and Gregory et al. (2004).
Claims17
A method of treating autoimmune disorder or ameliorating one or more symptoms thereof, comprising administering to a patient in need thereof an effective amount of a composition comprising a population of T cells with regulatory activity (T regs) obtained by adding IL-10 to autologous CD4+ T cells and to autologous apoptotic peripheral blood mononuclear cells (ACs), incubating the autologous CD4+ T cells and the ACs in the presence of the added IL-10.
A method of treating atopic disease or ameliorating one or more symptoms thereof comprising administering to a patient in need thereof an effective amount of a composition comprising a population of T cells with regulatory activity (T regs) obtained by adding IL-10 to autologous CD4+ T cells and to autologous apoptotic peripheral blood mononuclear cells (ACs), incubating the autologous CD4+ T cells and the ACs in the presence of the added IL-10.
A method of treating a patient with a disorder or the predisposition for a disorder comprising testing the patient to determine whether the patient has a disorder, and administering to a patient in need thereof an effective amount of a composition comprising a population of T cells with regulatory activity (T regs) obtained by adding IL-10 to autologous CD4+ T cells and to autologous apoptotic peripheral blood mononuclear cells (ACs), incubating the autologous CD4+ T cells and the ACs in the presence of the added IL-10.
Dependencies are inferred from the claim text.