Method for producing polyethylene glycol having terminal carboxyl group
AssigneeNof Corporation
InventorsAkiko DOI, Takashi ICHIKAWA, Tsuyoshi TAKEHANA, Takuma TSUBUSAKI
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Abstract
A method for producing polyethylene glycol having a terminal carboxyl group including oxidizing polyethylene glycol represented by formula (I): CH3O(CH2CH2O)n(CH2)m—CHO with potassium peroxymonosulfate in water whose pH is adjusted to be from 6 to 8 with at least one selected from a carbonate, a phosphate, a citrate and an acetate at 5 to 40° C. to produce polyethylene glycol represented by formula (II): CH3O(CH2CH2O)n(CH2)m—COOH, wherein n is a number from 10 to 1,100, and m is 2 or 3.
Claims2
A method for producing polyethylene glycol having a terminal carboxyl group, comprising oxidizing polyethylene glycol represented by formula (I) with potassium peroxymonosulfate in water whose pH is adjusted to be from 6 to 8 with at least one selected from the group consisting of a carbonate, a phosphate, a citrate and an acetate at 5 to 40° C. to produce polyethylene glycol represented by formula (II):
- CH3O(CH2CH2O)n(CH2)m—CHO (I)
- (in the formula, n is a number from 10 to 1,100, and m is 2 or 3);
- CH3O(CH2CH2O)n(CH2)m—COOH (II)
- (in the formula, n and m have same meanings as defined above).
Dependencies are inferred from the claim text.