Anti-mesothelin binding proteins
AssigneeAmgen Inc.
InventorsWilliam Christian Fanslow, III, Carl Kozlosky, Jean Marie Gudas
Life of this patent
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Abstract
The present disclosure provides compositions and methods relating to antigen binding proteins, in particular, antibodies and bispecific antibodies which specifically bind to mesothelin. The disclosure provides nucleic acids encoding such antigen binding proteins and antibodies and methods of making and using such antibodies, including methods of treating and preventing cancer or other hypoproliferative disorders and related disorders by administering such antigen binding proteins and antibodies to a subject in need of such treatment.
Claims9
1-34. (canceled)
An isolated nucleic acid encoding an antibody, antigen binding protein, or fragment thereof, wherein the antibody, antigen binding protein, or fragment thereof comprises a mesothelin binding domain comprising three heavy chain CDRs and three light chain CDRs with sequences selected from the group consisting of:
- a) SEQ ID NOs:
- 45, 46, and 47 of the heavy chain and SEQ ID NOs:
- 9, 10, and 11 of the light chain;
- b) SEQ ID NOs:
- 48, 49, and 50 of the heavy chain and SEQ ID NOs:
- 12, 13, and 14 of the light chain;
- c) SEQ ID NOs:
- 51, 52, and 53 of the heavy chain and SEQ ID NOs:
- 15, 16, and 17 of the light chain;
- d) SEQ ID NOs:
- 51, 52, and 53 of the heavy chain and SEQ ID NOs:
- 18, 19, and 20 of the light chain;
- e) SEQ ID NOs:
- 54, 55, and 56 of the heavy chain and SEQ ID NOs:
- 21, 22, and 23 of the light chain;
- f) SEQ ID NOs:
- 57, 58, and 59 of the heavy chain and SEQ ID NOs:
- 24, 25, and 26 of the light chain;
- g) SEQ ID NOs:
- 60, 61, and 62 of the heavy chain and SEQ ID NOs:
- 27, 28, and 29 of the light chain;
- h) SEQ ID NOs:
- 63, 64, and 65 of the heavy chain and SEQ ID NOs:
- 30, 31, and 32 of the light chain;
- i) SEQ ID NOs:
- 63, 64, and 65 of the heavy chain and SEQ ID NOs:
- 33, 34, and 35 of the light chain;
- j) SEQ ID NOs:
- 63, 64, and 65 of the heavy chain and SEQ ID NOs:
- 36, 37, and 38 of the light chain, and
- k) any one of (a)-(j), wherein each of said CDRs are identical to or comprise 1, 2, or 3 amino acid residue substitutions relative to their specified sequence.
A method of inhibiting or reducing the growth of mesothelin expressing tumor cells in a subject, comprising administering to said animal a therapeutically effective dose of the antibody or antigen binding protein or fragment thereof of claim 1.
42-45. (canceled)
Dependencies are inferred from the claim text.