Treatment of central nervous system disorders by intranasal administration of immunoglobulin g
AssigneeBaxalta Incorporated
InventorsWilliam H. Frey, II, Leah Ranae Bresin Hanson, Sharon Pokropinski, Francisco M. Rausa, III
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Abstract
The present invention provides, among other aspects, methods and compositions for treating a central nervous system (CNS) disorder by delivering a therapeutically effective amount of a composition of pooled human immunoglobulin G (IgG) to the brain via intranasal administration of the composition directly to the olfactory epithelium of the nasal cavity. In particular, methods and compositions for treating Alzheimer's disease are provided.
Claims40
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A method for treating a central nervous system (CNS) disorder in a subject in need thereof, the method comprising:
- delivering a therapeutically effective amount of a composition comprising pooled human immunoglobulin G (IgG) to the brain of the subject,
- wherein delivering the composition to the brain comprises intranasally administering the composition to a nasal epithelium of the subject associated with trigeminal nerve endings,
- wherein at least 40% of the pooled human IgG administered to the subject contacts the nasal epithelium of the subject associated with trigeminal nerve endings.
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Dependencies are inferred from the claim text.