Chimeric antigen receptor molecules and uses thereof
AssigneeBoard of Regents, The University of Texas System
InventorsRadhika THOKALA, Laurence J.N. COOPER, Simon OLIVARES
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Abstract
Chimeric antigen receptor (CAR) polypeptides are provided comprising an antigen binding domain; a hinge domain; a transmembrane domain and an intracellular signaling domain, wherein the CAR polypeptide binds to a target antigen and wherein the antigen binding domain comprises HCDR sequences from a first antibody that binds to the target antigen and LCDR sequences from a second antibody that binds to the target antigen. In certain aspects, the target antigen is CD123.
Claims22
A chimeric antigen receptor (CAR) polypeptide comprising, from N- to C-terminus, an antigen binding domain;
- a hinge domain;
- a transmembrane domain and an intracellular signaling domain, wherein the CAR polypeptide binds to a target antigen and wherein the antigen binding domain comprises HCDR sequences from a first antibody that binds to the target antigen and LCDR sequences from a second antibody that binds to the target antigen.
Dependencies are inferred from the claim text.