Glucagon analogues

A compound having the formula:

• R1—X—OH
• wherein
• R1 is H, C1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl;
• and X is a peptide which has the formula:
• (SEQ ID NO:
• 3)
• HSQGTFTSDYSKYLDSKAAHDFVEWLLRA
• (SEQ ID NO:
• 13)
• H-Aib-QGTFTSDYSKYLDSKAAHDFVEWLLSA
• (SEQ ID NO:
• 14)
• H-Aib-QGTFTSDYSKYLDEKRAKDFIEWLLSA
• or a pharmaceutically acceptable salt thereof.

A compound having the formula:

• R1—X—Z—R2
• wherein
• R1 is H, C1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl;
• R2 is OH or NH2;
• X is a peptide of SEQ ID NO:
• 15:
• (SEQ ID NO:
• 15)
• H-Aib-QGTFTSDYSKYLDEKAAKDFIEWLESA
• or which differs from SEQ ID NO:
• 15 at up to three of the following positions whereby, if different from SEQ ID NO:
• 15:
• the residue at position 2 is selected from Ser and D-Ser
• the residue at position 3 is selected from His and Hse
• the residue at position 12 is Arg
• the residue at position 15 is Glu
• the residue at position 16 is Ser
• the residue at position 18 is Arg
• the residue at position 20 is selected from His and Glu
• the residue at position 21 is Glu
• the residue at position 23 is Val
• the residue at position 28 is selected from Arg and Glu
• the residue at position 29 is absent;
• and Z is absent or is a sequence of 1-20 amino acid units independently selected from the group consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, Dpr and Orn;
• or a pharmaceutically acceptable salt thereof.

A compound having the formula:

• R1—X—Z—R2
• wherein
• R1 is H, C1-4 alkyl, acetyl, formyl, benzoyl or trifluoroacetyl;
• R2 is OH or NH2;
• X is a peptide of SEQ ID NO:
• 16:
• (SEQ ID NO:
• 16)
• H-Aib-QGTFTSDYSKYLDSKAAEDFVEWLESA
• or which differs from SEQ ID NO:
• 16 at up to three of the following positions whereby, if different from SEQ ID NO:
• 16:
• the residue at position 2 is selected from Ser and D-Ser
• the residue at position 3 is selected from His and Hse
• the residue at position 12 is Arg
• the residue at position 15 is Glu
• the residue at position 16 is Glu
• the residue at position 18 is Arg
• the residue at position 20 is selected from Lys and His
• the residue at position 21 is Glu
• the residue at position 23 is Ile
• the residue at position 28 is selected from Arg and Glu
• the residue at position 29 is absent
• and Z is absent or is a sequence of 1-20 amino acid units independently selected from the group consisting of Ala, Leu, Ser, Thr, Tyr, Cys, Glu, Lys, Arg, Dbu, Dpr and Orn;
• or a pharmaceutically acceptable salt thereof.