Stabilized human immunodeficiency virus (hiv) envelope (env) trimer vaccines and methods of using same
AssigneeBeth Israel Deaconess Medical Center, Inc.
InventorsDan H. BAROUCH, Joseph Patrick NKOLOLA
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Abstract
The invention features stabilized human immunodeficiency virus (HIV) envelope (Env) trimers. The invention also features vaccines, nucleic acids, and vectors to deliver and/or facilitate production of the stabilized HIV Env trimers. In addition, the invention features methods of making and using the stabilized HIV Env trimers of the invention.
Claims22
1-37. (canceled)
An oligomeric protein comprising three gp140 polypeptides, wherein at least one of said gp140 polypeptides comprises an amino acid sequence comprising amino acids 30-724 of SEQ ID NO:2.
An oligomeric protein comprising three gp140 polypeptides, wherein the oligomeric protein is obtained in eukaryotic cell culture by expressing a nucleic acid sequence encoding a gp140 polypeptide comprising the amino acid sequence of SEQ ID NO:2.
An oligomeric protein comprising three gp140 polypeptides, wherein each of said gp140 polypeptides comprises the amino acid sequence of SEQ ID NO:2.
Dependencies are inferred from the claim text.