6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds

A compound of Formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is a substituent selected from the group consisting of (C3-C8)cycloalkyl, (4- to 10-membered)heterocycloalkyl, (C6-C10)aryl, and (5- to 10-membered)heteroaryl, wherein the (C3-C8)cycloalkyl, (4- to 10-membered)heterocycloalkyl, (C6-C10)aryl and (5- to 10-membered)heteroaryl are optionally substituted with one to five R5;
• R2 and R3 are each independently selected from the group consisting of hydrogen, optionally substituted (C1-C6)alkyl, (C3-C8)cycloalkyl, (4- to 10-membered)heterocycloalkyl, (C6-C10)aryl, and (5- to 10-membered)heteroaryl, wherein the (C3-C8)cycloalkyl, (4- to 10-membered)heterocycloalkyl, (C6-C10)aryl, and (5- to 10-membered)heteroaryl are optionally substituted with one to five R6;
• or
• R2 and R3 taken together with the nitrogen to which they are attached form a (4- to 10-membered)heterocycloalkyl or a (5- to 10-membered)heteroaryl, wherein the (4- to 10-membered)heterocycloalkyl and (5- to 10-membered)heteroaryl are optionally substituted with one to five R6;
• when present, R4, at each occurrence, is independently selected from the group consisting of halogen, cyano, hydroxy, —SF5, nitro, optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, optionally substituted (C1-C6)alkylthio, optionally substituted (C1-C6)alkoxy, —N(R7)(R8), —N(R7)(C═(O)R8), —C(═O)N(R7)(R8), —O—C(═O)—N(R7)(R8), —C(═O)—R7, and —C(═O)—OR7;
• when present, R5 and R6, at each occurrence, are independently selected from the group consisting of halogen, oxo, cyano, hydroxy, —SF5, nitro, optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, optionally substituted (C1-C6)alkylthio, optionally substituted (C1-C6)alkoxy, —N(R7)(R8), —N(R7)(C═(O)R8), —C(═O)N(R7)(R8), —O—C(═O)—N(R7)(R8), —C(═O)—R7, and —C(═O)—OR7;
• R7 and R8 at each occurrence are independently selected from the group consisting of hydrogen and (C1-C6)alkyl;
• and
• a is represented by an integer selected from 0, 1, 2 or 3.