Toll-like receptor 7 (tlr7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor

A compound represented by formula (I) or (II)

• wherein
• R1 is (C1-C5 alkyl)O, (C1-C2 alkyl)O(CH2)2-3O, (C1-C5 alkyl)C(═O)O, (C1-C5 alkyl)NH, (C1-C2 alkyl)O(CH2)2-3NH, or (C1-C5 alkyl)C(═O)NH;
• R2 is, independently for each occurrence thereof, H, C1-C3 alkyl, halo, O(C1-C3 alkyl), CN, or NO2;
• X is, independently for each occurrence thereof, CR2 or N;
• R3 is O, S, NH, or N(C1-C3 alkyl);
• Ar is
• where one of Y, Y′ and Y″ is selected from —O—, —S—, —NH— and —N(C1-C3 alkyl)- and the other two of Y, Y′, and Y″ are selected from ═N— and ═CR2—;
• R4 is H, C1-C3 alkyl, halo, O(C1-C3 alkyl), CN, NO2, or (CH2)xR5, where the subscript x is 1, 2, 3, or 4;
• and
• R5 is H, halo, OH, CN, NH2, NH(C1-C5 alkyl), N(C1-C5 alkyl)2, NH(C3-C6 cycloalkyl), NH(C4-C8 bicycloalkyl), NH(C6-C10 spirocycloalkyl), N(C3-C6 cycloalkyl)2, NH(CH2)1-3(aryl), N((CH2)1-3(aryl))2, a cyclic amine moiety having the structure
• a 6-membered aromatic or heteroaromatic moiety or a 5-membered heteroaromatic moiety;
• wherein
• an alkyl, cycloalkyl, bicycloalkyl, spriocycloalkyl, cyclic amine, 6-membered aromatic or heteroaromatic, or 5-membered heteroaromatic moiety is optionally substituted with one or more substituents selected from OH, halo, CN, (C1-C3 alkyl), O(C1-C3 alkyl), C(═O)(Me), SO2(C1-C3 alkyl), C(═O)(Et), NH2, NH(Me), N(Me)2, NH(Et), N(Et)2, and N(C1-C3 alkyl)2;
• and
• a cycloalkyl, bicycloalkyl, sprioalkyl, or cyclic amine moiety may have a CH2 group replaced by O, S, NH, N(C1-C3 alkyl), or N(Boc).