Inhibitors of lysine specific demethylase-1
AssigneeCelgene Quanticel Research, Inc.
InventorsYoung K. Chen, Toufike Kanouni, Stephen W. Kaldor, Jeffrey Alan Stafford, James Marvin Veal
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Abstract
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of lysine specific demethylase-1. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
Claims46
A compound having the structure of Formula (II), or a pharmaceutically acceptable salt thereof,
- wherein,
- X and Y are each independently chosen from C—H, C—F, C—CH3, or N;
- W is chosen from C—H, C—F, C—Cl, C—CH3, C—CF3, C—OCH3, C—OCH2CH3, or N;
- Z is chosen -G, —CH2-G, —CH2—CH2-G, —N(R1)-G, —N(R1)—CH2-G, —O-G, —O—CH2-G, or —C(O)N(R2)(R3);
- G is carbocyclyl, aryl, heterocyclyl or heteroaryl;
- R1 is hydrogen or alkyl;
- R2 and R3 are independently selected from hydrogen, alkyl, heterocyclyl, heterocyclylalkyl, or optionally, R2 and R3 join to form an N-linked heterocyclyl ring system;
- R is chosen from aryl, halogen, heteroaryl, heterocyclyl, carbocyclyl, alkoxy, cycloalkylalkyloxy, aralkyloxy or heteroaralkyloxy.
A compound, or pharmaceutically acceptable salt thereof selected from the group consisting of:
- 4-[5-(4-methylphenyl)-3-(pyrrolidin-3-ylmethylamino)pyrazol-1-yl]benzonitrile;
- 4-[5-(4-methylphenyl)-3-[[(3 S)-pyrrolidin-3-yl]methylamino]pyrazol-1-yl]benzonitrile;
- 4-[5-(4-methylphenyl)-3-[[(3R)-pyrrolidin-3-yl]methylamino]pyrazol-1-yl]benzonitrile;
- 4-[5-(4-methylphenyl)-3-(piperidin-4-ylmethylamino)pyrazol-1-yl]benzonitrile;
- 4-[3-[[(1 S,5R)-3-azabicyclo[3.1.0]hexan-6-yl]methylamino]-5-(4-methylphenyl)pyrazol-1-yl]benzonitrile;
- 4-{3-[((3R)-3-aminopiperidyl)carbonyl]-5-(2-pyridylmethoxy)pyrazolyl}benzenecarbonitrile;
- 4-{3-[((3R)-3-aminopiperidyl) carbonyl]-5-(3-pyridylmethoxy) pyrazolyl}benzenecarbonitrile;
- and
- 4-(3-[((3R)-3-aminopiperidyl) carbonyl]-5-(4-pyridylmethoxy) pyrazolyl benzenecarbonitrile.
Dependencies are inferred from the claim text.