Acid addition salts of piperazine derivatives

An acid addition salt of hydrochloric acid, maleic acid, tartaric acid, sulfuric acid or p-toluolsulfonic acid with compounds of formula I

• wherein:
• X denotes O or CH2;
• n denotes 0 or 1;
• and
• Q denotes one of the following groups:
• Z1 is S, O, NR3;
• Z2, Z2′, Z3 independently denote CR5, CR6 or N;
• R5, R5′, R6, R7 independently denote H, Hal, NR3R4, NO2, straight chain or branched alkyl having 1 to 12 carbon atoms, wherein 1 to 3 CH2-groups may be replaced by a group selected from O, NR3, S, SO, SO2, CO, COO, OCO, CONR3, NR3CO and wherein 1 to 5 hydrogen atoms may be replaced by Hal, NR3R4, NO2, OR3, Het, Ar, Cyc, or denote Ar, Het or Cyc;
• R8 denotes H, methyl or straight chain or branched alkyl having 2 to 12 carbon atoms, wherein 1 to 3 CH2-groups may be replaced by a group selected from O, NR3, S, SO, SO2, CO, COO, OCO, CONR3, NR3CO and wherein 1 to 5 hydrogen atoms may be replaced by Hal, NR3R4 or NO2;
• R3, R4 denote each independently H or a straight chain or branched alkyl group having 1 to 12 carbon atoms;
• Hal denotes F, Cl, Br or I;
• Het denotes a saturated, unsaturated or aromatic ring, being monocyclic or bicyclic or fused-bicyclic and having 3- to 8-members and containing 1 to 4 heteroatoms selected from N, O and S, which may be substituted by 1 to 3 substituents selected from R5, Hal and OR3;
• Ar denotes a 6-membered carbocyclic aromatic ring or a fused or non-fused bicyclic aromatic ring system, which is optionally substituted by 1 to 3 substituents independently selected from R5, OR3 and Hal;
• Cyc denotes a saturated or an unsaturated carbocyclic ring having from 3 to 8 carbon atoms which is optionally substituted by 1 to 3 substituents independently selected from R5 or Hal or OH;
• as well as solid forms thereof.