Bace1 inhibitors
AssigneeHoffmann-La Roche Inc.
InventorsWolfgang HAAP, Thomas WOLTERING
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Abstract
The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compound of the present invention is useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
Claims13
A compound of formula I:
- or pharmaceutically acceptable salt thereof.
A compound, wherein said compound is N-[6 [(4R,5R,6S)-2-amino-5-fluoro-4-methyl-6-(trifluoromethyl)-5,6-dihydro-1,3-oxazin-4-yl]-5-fluoro-2-pyridyl]-5-cyano-3-methyl-pyridine-2-carboxamide.
A metabolite M1:
- of a compound of formula I:
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Dependencies are inferred from the claim text.